SP2 has been out now for Exchange 2010 for a little while. I’ve experienced many issues over the time I’ve supported Exchange 2010 since RTM. The first RTM didn’t play very nice with Forefront Protection at all.
Here are some steps to sucucessfully install this on a server running TMG 2010 and Forefront Protection.
1) Make sure you have a good backup
2) Stop the TMG Managed Control service and any backup agents. This is a requirement of the Exchange setup. Note: there is no problem doing this remotely.
3) Install SP2
4) If you have any issues with services, reboot and you should be fine.
The install all went smoothly.